Author:
Saffer J D,Jackson S P,Thurston S J
Abstract
Expression of the trans-acting transcription factor Sp1 increased almost 10-fold after infection of cells by simian virus 40. This alteration, attributable to an early viral protein, occurred at the mRNA level beginning at 12 hr postinfection, shortly after the appearance of viral T antigen, and reached a plateau at 20 hr postinfection. The enhanced level of Sp1 message was accompanied by a marked increase in Sp1 protein in the cell nuclei. Furthermore, we have demonstrated that stimulation of Sp1 levels elevates expression from viral and cellular promoters. Enhancing the amount of this trans-acting factor may play a role in aiding the viral life cycle and in neoplastic transformation of infected cells.
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Reference51 articles.
1. Acheson, N.H. 1981. Lytic cycle of SV40 and polyoma virus. In DNA tumor viruses (ed. J. Tooze), pp. 125–204. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
2. Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas
3. A transcription factor from simian virus 40 chromosomes which activates the viral late promoter in vitro.;J. Virol.,1988
4. Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1
5. RNA is covalently linked to SV40 large T antigen.;Oncogene,1988
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