Author:
Holahan Matthew R.,White Norman M.
Abstract
Rats were trained by shocking them in a closed compartment. When
subsequently tested in the same closed compartment with no shock, normal rats
showed an increased tendency to freeze. They also showed an increased tendency
to actively avoid the compartment when given access to an adjacent neutral
compartment for the first time. Amygdala inactivation with bilateral muscimol
injections before training attenuated freezing and eliminated avoidance during
the test. Rats trained in a normal state and given intra-amygdala muscimol
injections before the test did not freeze or avoid the shock-paired
compartment. This pattern of effects suggests that amygdala inactivation
during training impaired acquisition of a conditioned response (CR) due either
to inactivation of a neural substrate essential for its storage or to
elimination of a memory modulation effect that facilitates its storage in some
other brain region(s). The elimination of both freezing and active avoidance
by amygdala inactivation during testing suggests that neither of these
behaviors is the CR. The possibility that the CR is a set of internal
responses that produces both freezing and avoidance as well as other
behavioral effects is discussed.
Publisher
Cold Spring Harbor Laboratory
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neuropsychology and Physiological Psychology
Cited by
21 articles.
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