Shedding of Infectious SARS-CoV-2 Despite Vaccination

Author:

Riemersma Kasen K.,Grogan Brittany E.,Kita-Yarbro Amanda,Halfmann Peter J.,Segaloff Hannah E.,Kocharian Anna,Florek Kelsey R.,Westergaard Ryan,Bateman Allen,Jeppson Gunnar E.,Kawaoka Yoshihiro,O’Connor David H.ORCID,Friedrich Thomas C.ORCID,Grande Katarina M.

Abstract

AbstractThe SARS-CoV-2 Delta variant is highly transmissible and contains mutations that confer partial immune escape. We compared RT-PCR cycle threshold (Ct) data from 699 test-positive anterior nasal swab specimens from fully vaccinated (n = 310) or unvaccinated (n=389) individuals. We observed low Ct values (<25) in 212 of 310 fully vaccinated (68%) and 246 of 389 (63%) unvaccinated individuals. Testing a subset of these low-Ct samples revealed infectious SARS-CoV-2 in 15 of 17 specimens (88%) from unvaccinated individuals and 37 of 39 (95%) from vaccinated people. To determine whether infectious virus titers differed in vaccinated and unvaccinated persons, we performed plaque assays on an additional set of 48 samples with Ct <25, finding no difference in infectious virus titer between groups.

Publisher

Cold Spring Harbor Laboratory

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