Statistical approach for …a test chemical is considered to be positive… in regulatory toxicology: Trend and pairwise tests

Abstract

AbstractIn regulatory toxicology an outcome is claimed positive when both a trend is significant and any pairwise test against control. Two statistical approaches are proposed: a joint Dunnett and Williams test (assuming the dose as a qualitative factor) and a joint test of the Tukey regression test and Dunnett test (assuming the dose as a quantitative covariate). Related R software is available.