Author:
Simond Alexandra M.,Ling Chen,Moore Michaela J.,Condotta Stephanie A.,Richer Martin J.,Muller William J.
Abstract
Mutations in the estrogen receptor α (ERα) occur in endocrine-resistant metastatic breast cancer. However, a major gap persists with the lack of genetically tractable immune competent mouse models to study disease. Hence, we developed a Cre-inducible murine model expressing a point-activated ESR1Y541S (ESR1Y537S in humans) driven by its endogenous promoter. Germline expression of mutant ESR1Y541S reveals dramatic developmental defects in the reproductive organs, mammary glands, and bones of the mice. These observations provide critical insights into the tissue-specific roles of ERα during development and highlights the potential use of our model in further developmental and cancer studies.
Funder
Canadian Institutes of Health Research
Canada Research Chair in Molecular Oncology
CIHR
Fonds de Recherche du Québec Santé-Chercheurs-Boursiers Junior 1
Dr. Victor K.S. Lui Studentship
Michael D'Avirro Fellowship in Molecular Oncology Research
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
10 articles.
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