Abstract
AbstractThe UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on almost 500,000 individuals from across the United Kingdom. Within this dataset, we carefully define 21 distinct ancestry groups from all four corners of the world. These ancestry groups can serve as a global reference of worldwide populations, with a handful of applications. As an example application here, we use allele frequencies derived from these ancestry groups to effectively measure diversity from summary statistics of any genetic dataset. Measuring genetic diversity is an important problem because increasing genetic diversity is key to making new genetic discoveries, while also being a major source of confounding to be aware of in genetics studies.
Publisher
Cold Spring Harbor Laboratory
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