Re-emergence of Invasive Pneumococcal Disease in Germany during the Spring and Summer of 2021-Reference-Cited by-同舟云学术

Re-emergence of Invasive Pneumococcal Disease in Germany during the Spring and Summer of 2021

Published:2021-10-18 Issue: Volume: Page:
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Author:

Perniciaro Stephanie^ORCID,van der Linden Mark^ORCID,Weinberger Daniel M.

Abstract

AbstractBackgroundThe incidence of invasive pneumococcal disease (IPD) decreased worldwide in 2020 and the first quarter of 2021, concurrent with non-pharmaceutical interventions (NPIs) intended to stymie transmission of SARS-CoV-2. In 2021, stringency of these NPI strategies has varied. We investigated age- and serotype-specific variations in IPD case counts in Germany in 2020-2021.MethodsIPD cases through July 31, 2021 were stratified by age group, serotype, or geographic location. IPD surveillance data in 2020-2021 were compared with: 1) IPD surveillance data from 2015-2019, 2) mobility data during 2020 and 2021, and 3) NPI stringency data in 2020 and 2021.ResultsIPD began to return towards baseline values among children 0 to 4 years old in April 2021 and exceeded baseline levels by June 2021 (a 9% increase over the average monthly values for 2015-2019). Children 5 to 14, adults aged 15-34 and adults 80 years and older showed increases in IPD cases which went over baseline values starting in July 2021, with increases also starting in Spring 2021. The age distribution and proportion of vaccine serotype IPD remained comparable to previous years despite lower overall case counts in 2020 and 2021. The percent change in IPD incidence compared to the previous five years correlated with changes in mobility and with NPI stringency.ConclusionsIPD levels began to return to and exceed seasonal levels in Spring/Summer 2021 in Germany following sharp declines in 2020 that coincided with NPIs related to the COVID-19 pandemic. Proportions of vaccine serotypes remained largely consistent throughout 2020-2021.

Publisher

Cold Spring Harbor Laboratory

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