S-phase induced RNAs initiate formation of DNA replication origins-Reference-Cited by-同舟云学术

S-phase induced RNAs initiate formation of DNA replication origins

Published:2021-10-20 Issue: Volume: Page:
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Author:

Ummarino Simone^ORCID,Ebralidze Alex K.,Monteleone Emanuele^ORCID,Zhang Yhanzou,Trinh Bon Q.^ORCID,Di Ruscio Annalisa^ORCID,Tenen Daniel G.^ORCID

Abstract

AbstractThe mechanistic events leading to alterations of DNA replication in normal and diseased cells remain unknown. The present study uncovers the role of a new class of non-coding RNAs induced in early S-phase, able to activate and repress replication origins formation. The discovery of a RNA-mediated mechanism governing the replication of c-MYC locus offers novel strategies to control DNA replication by modulating transcriptional activity, and pave the way for future clinical applications to treat cancer and genetic disorders.

Publisher

Cold Spring Harbor Laboratory

Reference18 articles.

1. A predictable conserved DNA base composition signature defines human core DNA replication origins;Nat Commun,2020

2. Genome-wide mapping of human DNA-replication origins: Levels of transcription at ORC1 sites regulate origin selection and replication timing

3. Ebralidze, A. K. , S. Ummarino ;, M. A. Bassal ;, H. Zhang ;, B. Budnik ;, E. Monteleone ;, D. Kappei ;, Y. V. Liu ;, D. E. Tenen ;, R. Coffey ;, M. R. Sheen ;, Y. Zhang ;, A. Wanet ;, B. Q. Trinh ;, V. Poli ;, V. E. Angarica ;, R. T. Magallanes ;, T. Benoukraf ;, C. CraneRobinson ;, A. D. Ruscio ; and D. G. Tenen ; (2021). “Formation and recycling of an active epigenetic mark mediated by cell cyclespecific RNAs.” Research square.

4. Replication stress and cancer

5. Fine mapping of a replication origin of human DNA.