Progressively shifting patterns of co-modulation among premotor cortex neurons carry dynamically similar signals during action execution and observation

Abstract

ABSTRACTMany neurons in the premotor cortex show firing rate modulation whether the subject performs an action or observes another individual performing the same action. Although such “mirror neurons” have been thought to have highly congruent discharge during execution and observation, many if not most show non-congruent activity. Studies of such neuronal populations have shown that the most prevalent patterns of co-modulation—captured as neural trajectories—pass through subspaces which are shared in part, but in part are visited exclusively during either execution or observation. These studies focused on reaching movements for which the neural trajectories show comparatively simple dynamical motifs. But the neural dynamics of hand movements are more complex. We developed a novel approach to examine prevalent patterns of co-modulation during execution and observation of a task that involved reaching, grasping and manipulation. Rather than following neural trajectories in subspaces that contain their entire time course, we identified time series of instantaneous subspaces, sampled trajectory segments at the times of selected behavioral events, and projected each segment into the series of instantaneous subspaces. We found that instantaneous neural subspaces were partially shared between execution and observation in only one of three monkeys and were otherwise exclusive to one context or the other. Nevertheless, the patterns during execution and observation could be aligned with canonical correlation, indicating that though distinct, neural representations during execution and observation show dynamical similarity that may enable the nervous system to recognize particular actions whether performed by the subject or by another individual.