Intratumoral Delivery of Chlorine Dioxide Exploits its ROS-like Properties: A Novel Paradigm for Effective Cancer Therapy

Author:

Liu XuewuORCID,Liu Zhaoyang,Liu Xueyan,Liu ShuangningORCID,Zhang Jiao

Abstract

AbstractReactive Oxygen Species (ROS) are potent oxidizing compounds renowned for their ability to eradicate cancer cells and facilitate tissue regeneration. In our research, we have discovered chlorine dioxide (CD), a substance that exhibits ROS-like properties and can be safely administered as a medicinal agent in the human body. Our study focuses on the utilization of intratumoral delivery of CD as a novel and efficacious approach for cancer therapy. Through intratumoral injections, CD selectively targets and eliminates cancer cells without promoting drug resistance. Furthermore, CD has demonstrated the capacity to elicit an immune response against cancer, thereby augmenting its therapeutic potential. We propose a groundbreaking paradigm for cancer treatment, employing intratumoral injections of CD, which holds great promise in prolonging the survival of cancer patients and transforming cancer into a manageable chronic condition. This approach harnesses the ROS-like properties of CD to effectively eradicate cancer cells while fostering tissue regeneration. By capitalizing on the unique characteristics of CD, we present a new avenue for enhancing patient outcomes in cancer therapy. Further research is warranted to optimize the administration protocols and dosage of CD, as well as to explore potential synergistic effects with other therapeutic agents. With ongoing investigation, the intratumoral delivery of CD represents a promising and innovative strategy for achieving effective cancer therapy.HighlightsChlorine dioxide: safe and effective, exhibits ROS-like properties for cancer elimination and tissue regeneration.Intratumoral delivery of chlorine dioxide: targets and eliminates cancer cells without promoting drug resistance.Chlorine dioxide stimulates an immune response against cancer, enhancing therapeutic potential.Intratumoral injections of chlorine dioxide: innovative strategy for effective cancer therapy.

Publisher

Cold Spring Harbor Laboratory

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