Framewise multi-echo distortion correction for superior functional MRI
Author:
Van Andrew N.ORCID, Montez David F., Laumann Timothy O., Suljic Vahdeta, Madison Thomas, Baden Noah J., Ramirez-Perez Nadeshka, Scheidter Kristen M., Monk Julia S., Whiting Forrest I., Adeyemo Babatunde, Chauvin Roselyne J.ORCID, Krimmel Samuel R., Metoki Athanasia, Rajesh Aishwarya, Roland Jarod L., Salo Taylor, Wang Anxu, Weldon Kimberly B., Sotiras Aristeidis, Shimony Joshua S., Kay Benjamin P., Nelson Steven M., Tervo-Clemmens Brenden, Marek Scott A.ORCID, Vizioli Luca, Yacoub Essa, Satterthwaite Theodore D.ORCID, Gordon Evan M., Fair Damien A., Tisdall M. DylanORCID, Dosenbach Nico U.F.
Abstract
AbstractFunctional MRI (fMRI) data are severely distorted by magnetic field (B0) inhomogeneities which currently must be corrected using separately acquired field map data. However, changes in the head position of a scanning participant across fMRI frames can cause changes in the B0 field, preventing accurate correction of geometric distortions. Additionally, field maps can be corrupted by movement during their acquisition, preventing distortion correction altogether. In this study, we use phase information from multi-echo (ME) fMRI data to dynamically sample distortion due to fluctuating B0 field inhomogeneity across frames by acquiring multiple echoes during a single EPI readout. Our distortion correction approach, MEDIC (Multi-Echo DIstortion Correction), accurately estimates B0 related distortions for each frame of multi-echo fMRI data. Here, we demonstrate that MEDIC’s framewise distortion correction produces improved alignment to anatomy and decreases the impact of head motion on resting-state functional connectivity (RSFC) maps, in higher motion data, when compared to the prior gold standard approach (i.e., TOPUP). Enhanced framewise distortion correction with MEDIC, without the requirement for field map collection, furthers the advantage of multi-echo over single-echo fMRI.
Publisher
Cold Spring Harbor Laboratory
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