Abstract
AbstractThis work is aimed at studying the effects of rifampicin resistance mutations on the synthesis of secondary metabolites with antioxidant and DNA-protective properties.We used probiotic strains of the genusBacillus:B. amyloliquefaciensB-1895 andB. subtilisKATMIRA1933.The antioxidant, DNA-protective activity, and the ability to suppress the SOS-response inB. amyloliquefaciensB-1895 andB. subtilisKATMIRA1933 rifampicin-resistant mutants have been studied for the first time. It has been found that antioxidant, DNA protective, and SOS-inhibiting activity is higher in rifampicin-resistant mutants than that of original strains.According to the study results, it has been discovered that the antioxidant, DNA-protective and SOS-inhibitory activity in mutantsB. amyloliquefaciensB-1895 andB. subtilisKATMIRA1933 resistant to rifampicin is higher than in control strains, which indirectly proves the pleiotropic effect of therpoBgene on these activities.
Publisher
Cold Spring Harbor Laboratory
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