Effects of Maternal Fortified Balanced Energy-Protein Supplementation on the Mother-Infant Gut Microbiome: A Sub-Study of the MISAME-III Randomized Controlled Trial

Author:

Deng LishiORCID,Taelman SteffORCID,Olm Matthew R.,Toé Laéticia CélineORCID,Balini Eva,Ouédraogo Lionel,Bastos-Moreira YuriORCID,Argaw AlemayehuORCID,Tesfamariam KokebORCID,Sonnenburg Erica D.,Ouédraogo MoctarORCID,Ganaba RasmanéORCID,van Criekinge WimORCID,Kolsteren PatrickORCID,Stock MichielORCID,Lachat Carl,Sonnenburg Justin L.,Dailey-Chwalibóg TrentonORCID

Abstract

AbstractBiological pathways, including individual gut microbiome are potential barriers for maternal nutritional supplementation to improvement in infant growth. We evaluated the impact of balanced energy-protein (BEP) supplementation during pregnancy and the first six months of lactation on the composition and functionality of gut microbiome in mothers and their infants in rural Burkina Faso. Our findings reveal that BEP supplementation led to a significant increase in microbiome diversity during pregnancy. In the second trimester, there was a notable decrease in the abundance of anOscillospiraceaespecies, while postpartum, the abundance ofBacteroides fragilisincreased. We identified concerted enriched or depleted microbial pathways associated with BEP supplementation, including the phosphotransferase system, a critical mechanism for bacterial carbohydrates uptake, which exhibited enrichment in infants born to BEP-supplemented mothers. Despite these observations, the intricate biological connections with other omics necessitate further analysis to fully elucidate the underlying comprehensive biological pathways.

Publisher

Cold Spring Harbor Laboratory

Reference64 articles.

1. Levels and trends in child malnutrition: UNICEF/WHO/World Bank Group joint child malnutrition estimates: key findings of the 2023 edition. https://www.who.int/publications-detail-redirect/9789240073791 (2023).

2. Maternal and child undernutrition and overweight in low-income and middle-income countries

3. Reversibility of stuntingL: epidemiological findings in children from developing countries;Reversibility Stunting Epidemiol. Find. Child. Dev. Ctries,1994

4. Worldwide Timing of Growth Faltering: Revisiting Implications for Interventions

5. Revisiting maternal and child undernutrition in low-income and middle-income countries: variable progress towards an unfinished agenda

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