Thermodynamic framework for nonequilibrium self-assembly of branched actin networks

Abstract

Branched actin networks are involved in a variety of cellular processes, most notably the formation of lamellipodia in the leading edge of the cell. These systems adapt to varying loads through force dependant assembly rates that allow the network density and material properties to be modulated. Recent experimental work has described growth and force feedback mechanisms in these systems. We seek to create a minimal model of this nonequilibrium self assembly process incorporating these mechanisms. Our results will show how constraints from stochastic thermodynamics and non-equilibrium thermodynamics may bound or constrain the structures that result in such processes. This will allow us to develop a minimal yet predictive thermodynamic framework for these kinds of force generating processes.