Synapse propensity of human memory CD8 T cells confers competitive advantage over naïve counterparts

Author:

Mayya VivekaORCID,Judokusumo EdwardORCID,Abu-Shah EnasORCID,Neiswanger WillieORCID,Kam Lance CORCID,Dustin Michael LORCID

Abstract

AbstractMemory T cells are endowed with multiple functional features that enable them to be more protective than naïve T cells against infectious threats. It is not known if memory cells have a higher synapse propensity, i.e. increased probability to form immature immunological synapses that then provide an entry into different modes of durable interaction with antigen presenting cells. Here we show that only human memory CD8 T cells have remarkably high synapse propensity compared to naïve counterparts. Such a dichotomy between naïve and memory cells is not observed within the human CD4 or murine CD8 T cell population. Increased surface expression of LFA1 contributes to the higher synapse propensity in human memory CD8 T cells. Finally, we show that higher synapse propensity in human memory CD8 T cells allows them to compete out naïve CD8 T cells from getting recruited to the response. This observation has implications for original antigenic sin and aging of the immune system in humans.

Publisher

Cold Spring Harbor Laboratory

Reference33 articles.

1. Mechanisms behind functional avidity maturation in T cells;Clinical & developmental immunology,2012

2. Functional avidity maturation of CD8+ T cells without selection of higher affinity TCR

3. Functional differences between memory and naive CD8 T cells

4. Qualitative Changes Accompany Memory T Cell Generation: Faster, More Effective Responses at Lower Doses of Antigen

5. Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells;J Immunol,1994

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