Author:
Vanshylla Kanika,Held Kathrin,Eser Tabea M.,Gruell Henning,Jain Kanika,Weiland Daniela,Muench Jan,Gruettner Berthold,Geldmacher Christof,Klein Florian
Abstract
AbstractHumanized mice have been critical for HIV-1 research, but are inefficient at mucosal HIV-1 transmission. We present a fetal tissue-independent model called CD34T+ with enhanced human leukocyte levels in the blood and improved T cell homing to the gut-associated lymphoid tissue. CD34T+ mice are highly permissive to intra-rectal HIV-1 infection, which can be prevented by infusion of broadly neutralizing antibodies. Therefore, CD34T+ mice provide a novel platform for mucosal HIV-1 transmission and prevention studies.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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