Abstract
AbstractWe examined several sensory-motor processing circuits inDrosophilaacross the lifespan and uncovered distinctive age-resilient and age-vulnerable trajectories in their established functional properties. We observed relatively little deterioration toward the end of lifespan in the giant-fiber (GF) and downstream circuit elements responsible for the jump-and-flight escape reflex. In contrast, we found substantial age-dependent modifications in the performance of GF inputs and other circuits driving flight motoneuron activities. Importantly, in high temperature (HT)-reared flies (29 °C), the characteristic age-dependent progression of these properties was largely maintained, albeit over a compressed time scale, lending support for the common practice of expeditingDrosophilaaging studies by HT rearing. We discovered shortened lifespans inCu2+/Zn2+Superoxide Dismutase 1(Sod) mutant flies were accompanied by alterations distinct from HT-reared flies, highlighting differential effects of oxidative vs temperature stressors. This work also establishes several age-vulnerable parameters that may serve as quantitative neurophysiological landmarks for aging inDrosophila.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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