A novel ultrasensitive assay for plasma p-tau217: performance in individuals with subjective cognitive decline and early Alzheimer’s disease

Author:

Gonzalez-Ortiz FernandoORCID,Ferreira Pamela C L,Gonzalez Armand,Montoliu-Gaya Laia,Ortiz-Romero Paula,Kac Przemyslaw R.,Turton Michael,Kvartsberg HlinORCID,Ashton Nicholas J.,Zetterberg Henrik,Harrison Peter,Bellaver BrunaORCID,Povala Guilherme,Villemagne Victor L.,Pascoal Tharick A.,Ganguli Mary,Cohen Anne D.,Miguillon Carolina,Contador Jose,Suarez-Calvet MarcORCID,Karikari Thomas K.ORCID,Blennow Kaj

Abstract

ABSTRACTINTRODUCTIONDetection of Alzheimer’s disease (AD) pathophysiology among cognitively unimpaired individuals and those experiencing subjective cognitive decline (SCD) remains challenging. Plasma p-tau217 is one of the most promising of the emerging biomarkers for AD. However, accessible methods are limited.METHODSWe employed a novel p-tau217 immunoassay (UGOT p-tau217) in four independent cohorts (n=308) including a cerebrospinal fluid (CSF) biomarker-classified cohort (Discovery), two cohorts consisting mostly of cognitively unimpaired participants (MYHAT and Pittsburgh), and a population-based cohort of individuals with SCD (β-AARC).RESULTSUGOT p-tau217 showed high accuracy (AUC= 0.80-0.91) identifying Aβ pathology, determined either by Aβ positron emission tomography or CSF Aβ42/40 ratio. In individuals experiencing SCD, UGOT p-tau217 showed high accuracy identifying those with a positive CSF Aβ42/40 ratio (AUC= 0.91).DISCUSSIONUGOT p-tau217 can be an easily accessible and efficient way to screen and monitor patients with suspected AD pathophysiology, even in the early stages of the continuum.

Publisher

Cold Spring Harbor Laboratory

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