Clinical Features and Vaccine Efficacy Analysis of COVID-19 patients in a Chongqing Shelter hospital in 2022

Author:

Luo YiNing,Zhao Mei,Zhao Xingyu,Qiao YanWen,Gao YanXia,Wu TingTing,Liu Weiwei,Ren Yi

Abstract

AbstractBackgroundThe long-term impact of coronavirus disease 2019 (COVID-19) on many aspects of society emphasizes the necessity of vaccination and nucleic acid conversion time as markers of prevention and diagnosis. However, little research has been conducted on the immunological effects of vaccines and the influencing factors of virus clearance. Epidemiological characteristics and factors related to disease prognosis and nucleic acid conversion time need to be explored.Design and participantsWe reviewed published documentation to create an initial draft. The data were then statistically evaluated to determine their link. Given that a Chongqing shelter hospital is typical in terms of COVID-19 patients receiving hospital management and treatment effects, a retrospective analysis was conducted on 4,557 cases of COVID-19 infection in a shelter hospital in Chongqing in December 2022, which comprised 2,291 males and 2,266 females. The variables included age, medical history, nucleic acid conversion time, vaccination status, and clinical symptoms.ResultsUnivariate survival analysis using the Log-rank test (P < 0.05) showed that factors such as age significantly affected nucleic acid conversion time. COX regression analysis indicated a significant association between a history of hypertension and nucleic acid conversion time, which had a hazard ratio of 0.897 (95% CI: 0.811–0.992). A statistically significant difference was observed between vaccinated and unvaccinated infected individuals in terms of the presence of symptoms such as cough and sensory system manifestations (P < 0.05).ConclusionThe effect of vaccination against COVID-19 on symptoms such as coughing, nasal congestion, muscle aches, runny nose, and sensory system symptoms in COVID-19 patients was determined. Typical symptoms, such as runny nose, were generally higher in vaccinated than in unvaccinated ones; previous hypertension was an influential factor in nucleic acid conversion time in patients with COVID-19 infection.STRENGTHS AND LIMITATIONSThis study clarifies the advantages of vaccination by comparing the symptom development between patients who had received vaccinations and those who had not.This research suggests potential future study directions, such as investigating the impact of pre-existing diseases like hypertension on viral clearance time and assessing vaccine efficacy and safety in certain demographic groups.This work investigated data from 4,557 coronavirus disease 2019 patients admitted to a shelter hospital, which offered significant insights into patients’ clinical features and outcomes over a defined time span.This study has several flaws because a retrospective analysis method was used and not all confounding variables that might have affected the results were appropriately controlled.The overall research sample may not be representative of other communities because it was drawn from a shelter hospital in Chongqing, and the types of immunizations used were not disclosed. These factors might have had an impact on the precision and extent of the research findings.

Publisher

Cold Spring Harbor Laboratory

Reference41 articles.

1. COVID-19: Characteristics and Therapeutics

2. New Coronavirus Pneumonia Diagnosis and Treatment Program (Trial Ninth Edition).caj.

3. WHO Coronavirus (COVID-19) Dashboard. Accessed July 25, 2023. https://covid19.who.int

4. Episode #68 - COVID-19: Update on Long COVID. Accessed July 25, 2023. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/media-resources/science-in-5/episode-68-covid-19-update-on-long-covid

5. Analysis of factors influencing the time to nucleic acid test turnaround in 2019 coronavirus disease mild and common patients infected with the omicron variant strain;J Zhejiang Univ Med,2022

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3