Diagnostic Accuracy of Carotid Plaque Instability by Noninvasive Imaging: A Systematic Review and Meta-analysis

Author:

Pakizer DavidORCID,Kozel JiříORCID,Taffé Patrick,Elmers JolandaORCID,Feber JanuszORCID,Michel PatrikORCID,Školoudík DavidORCID,Sirimarco Gaia

Abstract

AbstractBackgroundThere is increasing evidence that plaque instability in the extracranial carotid artery may lead to an increased stroke risk independently of the degree of stenosis. We aimed to determine diagnostic accuracy of vulnerable and stable plaque using noninvasive imaging modalities when compared to histology in patients with symptomatic and asymptomatic carotid atherosclerosis.MethodsMedline Ovid, Embase, Cochrane Library, and Web of Science were searched for diagnostic accuracy of noninvasive imaging modalities (CT, MRI, US) in the detection of 1) vulnerable/stable plaque, and 2) vulnerable/stable plaque characteristics, compared to histology. The quality of included studies was assessed by QUADAS-2 and univariate and bivariate random-effect meta-analyses were performed.ResultsWe included 36 vulnerable and 5 stable plaque studies in the meta-analysis, and out of 211 plaque characteristics from remaining studies, we classified 169 as vulnerable and 42 as stable characteristics (28 CT, 120 MRI, 104 US characteristics). We found that MRI had high accuracy (90% [95% CI:82–95%]) in the detection of vulnerable plaque, similar to CT (86% [95% CI:76–92%]; p>0.05), whereas US showed less accuracy (80% [95% CI:75– 84%]; p=0.013). CT showed a high diagnostic accuracy to visualize characteristics of vulnerable or stable plaques (89% and 90%) similar to MRI (86% and 89%; p>0.05); however US had lower accuracy (77%, p<0.001 and 82%, p>0.05).ConclusionsCT and MRI have a similar, high performance to detect vulnerable carotid plaques, whereas US showed significantly less diagnostic accuracy. Moreover, MRI visualized all vulnerable plaque characteristics allowing for a better stroke risk assessment.RegistrationPROSPERO ID CRD42022329690 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=329690)

Publisher

Cold Spring Harbor Laboratory

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Relationship between carotid atherosclerosis and localization of ischemic stroke;Український радіологічний та онкологічний журнал;2024-07-02

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3