Widespread human exposure to ledanteviruses in Uganda – a population study

Author:

Shepherd James G.ORCID,Ashraf ShirinORCID,Salazar-Gonzalez Jesus F.,Salazar Maria G.,Downing Robert,Bukenya Henry,Jerome Hanna,Mpanga Joseph T.,Davis Chris,Tong Lily,Sreenu Vattipally B.,Atiku Linda A.,Logan Nicola,Kajik Ezekiel,Mukobi Yafesi,Mungujakisa Cyrus,Olowo Michael V.,Tibo Emmanuel,Wunna Fred,Ireland Hollie Jackson,Blunsum Andrew E.,Owolabi Iyanuoluwani,da Silva Filipe Ana,Bwogi Josephine,Willett Brian J.ORCID,Lutwama Julius J.,Streicker Daniel G.ORCID,Kaleebu Pontiano,Thomson Emma C.ORCID

Abstract

AbstractLe Dantec virus (LDV), type species of the genusLedanteviruswithin theRhabdoviridaehas been associated with human disease but has gone undetected since the 1970s. We describe the detection of LDV in a human case of undifferentiated fever in Uganda by metagenomic sequencing and demonstrate a serological response using ELISA and pseudotype neutralisation. By screening a cohort of 997 individuals sampled in 2016, we show frequent exposure to ledanteviruses with 76% of individuals seropositive in Western Uganda, but lower seroprevalence in other areas. Serological cross-reactivity as measured by pseudotype-based neutralisation was confined toLedantevirus,indicating population seropositivity may represent either exposure to LDV or related ledanteviruses. We also describe the discovery of a closely related ledantevirus, Odro virus, in the synanthropic rodentMastomys erythroleucus.Ledantevirusinfection is common in Uganda but is geographically heterogenous. Further surveys of patients presenting with acute fever are required to determine the contribution of these emerging viruses to febrile illness in Uganda.

Publisher

Cold Spring Harbor Laboratory

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