Effects of L-Dopa, SKF-38393 and Quinpirole on exploratory, anxiety- and depressive-like behaviors in pubertal female and male mice

Author:

Moraes Muiara AparecidaORCID,Árabe Laila BlancORCID,Resende Bruna Lopes,Codo Beatriz CamposORCID,de Araújo Lima Reis Ana Luiza,de Souza Bruno RezendeORCID

Abstract

AbstractAdolescence is a phase of substantial changes in the brain, characterized by maturational remodeling of many systems. This remodeling allows functional plasticity to adapt in a changing environment but turns this period into a neurodevelopmental vulnerable window. The dopaminergic system is under morphological and physiological changes during this phase. The disruption of its balance can lead to molecular variation and abnormal behavior - representing a risk factor for neuropsychiatric disorders. In the present study, we investigated if changes in the dopaminergic tone alter mice behavior in a receptor and sex-specific manner, specifically in the beginning of puberty period. We administered L-Dopa, SKF-38393 (D1 dopamine receptor agonist) and Quinpirole (D2 dopamine receptor agonist) and tested male and female mice motor, anxiety- and depressive-like behavior. While females displayed an impaired exploratory drive, males presented an intense depressive-like response. Our results provide insights into the function of dopaminergic development in adolescent behavior and highlight the importance of studies in this time window with male and female subjects.

Publisher

Cold Spring Harbor Laboratory

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