Author:
Klann Eric,Antion Marcia D.,Banko Jessica L.,Hou Lingfei
Abstract
It is widely accepted that protein synthesis, including local protein
synthesis at synapses, is required for several forms of synaptic plasticity.
Local protein synthesis enables synapses to control synaptic strength
independent of the cell body via rapid protein production from pre-existing
mRNA. Therefore, regulation of translation initiation is likely to be
intimately involved in modulating synaptic strength. Our understanding of the
translation-initiation process has expanded greatly in recent years. In this
review, we discuss various aspects of translation initiation, as well as
signaling pathways that might be involved in coupling neurotransmitter and
neurotrophin receptors to the translation machinery during various forms of
synaptic plasticity.
Publisher
Cold Spring Harbor Laboratory
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neuropsychology and Physiological Psychology
Cited by
96 articles.
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