X-ray crystallographic analyses of 14 IPMK inhibitor complexes

Abstract

AbstractInositol polyphosphate multikinase (IPMK) is a ubiquitously expressed kinase that has been linked to several cancers. Here, we report 14 new co-crystal structures (1.7Å - 2.0Å resolution) of human IPMK complexed with various IPMK inhibitors developed by another group. The new structures reveal two ordered water molecules that participate in hydrogen-bonding networks, and an unoccupied pocket in the ATP-binding site of human IPMK. New Protein Data Bank (PDB) codes of these IPMK crystal structures are:8V6W(1.95Å),8V6X(1.75Å),8V6Y(1.70Å),8V6Z(1.85Å),8V70(1.85Å),8V71(1.70Å),8V72(2.0Å),8V73(1.90Å),8V74(1.85Å),8V75(1.85Å),8V76(1.95Å),8V77(1.95Å),8V78(1.95Å),8V79(1.95Å).