Visual network modularity and communication alterations in ADHD subtypes: evidence from source localized EEG and graph theoretical analysis

Abstract

AbstractThe neurobiological basis of ADHD and its subtypes remains unclear, with inconsistent findings from studies using electrophysiology and neuroimaging. Some studies suggest ADHD-I is a distinct disorder, but there is also evidence of similar neural basis in ADHD-I and ADHD-C subtypes. This study investigates the neural basis of ADHD and its subtypes using a subnetwork modularity approach based on graph theoretical analysis of EEG data from 35 children aged 7-11. EEG was recorded in the eyes open condition and preprocessed. After preprocessing, data was analyzed using LORETA algorithm to estimate current densities in 84 regions of interest (ROIs) in the cortex and calculate functional connectivity between these ROIs in different EEG frequency bands. Then, we evaluated modularity of five functional brain networks (default mode, central control, salience, visual, and sensorimotor) using Newman modularity algorithm. Further, we evaluated edge betweenness centrality to assess communications between these functional brain networks. The study found that different brain networks have modularity in certain frequency bands, and ADHD groups showed reduced modularity of the visual network compared to normal groups in the alpha1 band (8-10 Hz). The communication between the visual network and other brain networks, except the salience network, was also reduced in ADHD groups (in the alpha1 band). However, there were no significant differences in the modularity of brain networks and communication among them between two ADHD subtypes. The results suggest a novel mechanism for ADHD involving lower intrinsic modularity in the visual network, disturbed communication between the visual network and other networks, and potential impact on the function of control and sensorimotor networks. Further, our results suggest that there may be a common neural basis for both subtypes, involving a shared disturbance in the modularity and connectivity of the ventral network. This supports the idea that ADHD-I and ADHD-C are subtypes within the same category and contradicts previous studies that suggest they are separate disorders.