Author:
Palacios Natalia,Gordon Scott,Wang Tao,Burk Robert,Qi Qibin,Huttenhower Curtis,Gonzalez Hector M.,Knight Robert,De Carli Charles,Daviglus Marta,Lamar Melissa,Telavera Gregory,Tarraf Wassim,Kosciolek Tomasz,Cai Jianwen,Kaplan Robert C.
Abstract
STRUCTURED ABSTRACTINTRODUCTIONWeconducted a study within the Hispanic Community Health Study/Study of Latinos- Investigation of Neurocognitive Aging (HCHS/SOL-INCA) cohort to examine the association between gut microbiome and cognitive function.METHODSWe analyzed the fecal metagenomes of 2,471 HCHS/SOL-INCA participants to, cross-sectionally, identify microbial taxonomic and functional features associated with global cognitive function. Omnibus (PERMANOVA) and feature-wise analyses (MaAsLin2) were conducted to identify microbiome-cognition associations, and specific microbial species and pathways (Kyoto Encyclopedia of Genes and Genomes (KEGG modules) associated with cognition.RESULTSEubacteriumspecies(E. siraeumandE. eligens), were associated with better cognition. Several KEGG modules, most strongly Ornithine, Serine biosynthesis and Urea Cycle, were associated with worse cognition.DISCUSSIONIn a large Hispanic/Latino cohort, we identified several microbial taxa and KEGG pathways associated with cognition.
Publisher
Cold Spring Harbor Laboratory