EndoGPT: A Proof-of-concept Large Language Model Based Assistant for the Management of Thyroid Nodules

Author:

Shah MeghalORCID,Kuo Eric J.ORCID,Kuo Jennifer H.ORCID,Hsu ShawnORCID,McManus CatherineORCID,Liou RachelORCID,Lee James A.ORCID,Sathe Tejas S.ORCID

Abstract

AbstractLarge language models (LLMs) are increasingly being explored for their potential to simulate clinical reasoning. Here, we demonstrate our initial experience using the GPT-4o LLM along with prompt engineering and knowledge retrieval to develop EndoGPT, a clinical decision support tool for the management of thyroid nodules. In a pilot study of 50 cases, EndoGPT demonstrated an 83% concordance rate with expert surgeons’ assessments and plans. The highest concordance was in diagnosis (93%), followed by the need for an operation (82%) and type of operation (69%). This work suggests that LLM-based assistants may play a useful role in assisting clinicians in the future.

Publisher

Cold Spring Harbor Laboratory

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