Abstract
AbstractAlzheimer Disease (AD) is associated with cerebral plaques and tangles, reduced synapse number, and shrinkage in several brain areas and these morphological effects are associated with the onset of compromised cognitive, motor, and anxiety-like behaviours. The focus of this study was to examine the effect of neonatal tactile stimulation on AD-like behavioural and neurological symptoms on APP NL-G-F/NL-G-F mice, a mouse model of AD. Our findings indicate that neonatal tactile stimulation improves cognition, motor skills, and anxiety-like symptoms in both gestationally stressed and non-stressed adult APP mice and that these alterations are associated with reduced Aβ plaque formation. Thus, tactile stimulation appears to be a promising non-invasive preventative strategy for slowing the onset of dementia in aging animals.
Publisher
Cold Spring Harbor Laboratory
Reference78 articles.
1. Tactile stimulation effects on hippocampal neurogenesis and spatial learning and memory in prenatally stressed rats;Brain Research Bulletin,2015
2. Antoniazzi, C. T. D. , Metz, V. G. , Roversi, K. , Freitas, D. L. , Vey, L. T. , Dias, V. T. , Segat, H. J. , Duarte, M. M. M. F. , & Burger, M. E. (2016). Tactile stimulation during different developmental periods modifies hippocampal BDNF and GR, affecting memory and behavior in adult rats. Hippocampus, Volume 27, Issue 2, https://doi.org/10.1002/hipo.22686
3. Depression and Alzheimer's Disease: Is Stress the Initiating Factor in a Common Neuropathological Cascade?
4. Neonatal Tactile Stimulations Affect Genetic Generalized Epilepsy and Comorbid Depression-Like Behaviors;Frontiers in behavioral neuroscience,2020
5. Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献