Author:
Shan Ying,Zhang Yucong,Zhao Yanping,Lu Yueqi,Chen Bangwei,Yang Liuqiao,Tan Cong,Bai Yong,Sang Yu,Liu Juehan,Jian Min,Ruan Lei,Zhang Cuntai,Li Tao
Abstract
AbstractAimsDeath due to cardiovascular diseases (CVD) increased significantly in China. One way to reduce CVD is to identify people at risk and provide targeted intervention. We aim to develop and validate a CVD risk prediction model for Chinese males (CVDMCM) to help clinicians identify those at risk of CVD and provide targeted intervention.Methods and ResultsWe conducted a retrospective cohort study of 2331 Chinese males without prior CVD to develop and internally validate the CVDMCM. These participants had a baseline physical examination record (2008-2016) and one revisit record by September 2019. With the full cohort, we used single factor cox regression to examine each candidate predictor adjusted for age. 16 sequential prediction models were built on significant predictors. CVDMCM was selected based on the Akaike information criterion, the area under the ROC curve, and the percentage of variation in outcome values explained by the model (R2). This model, the Framingham CVD risk model, and the Wu’s simplified model were all validated by bootstrapping with 1000 repetitions. CVDMCM’s C statistics (0.779, 95% CI: 0.733-0.825), D statistic (4.738, 95% CI: 3.270-6.864), and calibration plot demonstrated that CVDMCM outperformed the other two models.ConclusionsWe developed and internally validated CVDMCM, which predicted 4-year CVD risk for Chinese males with a better performance than Framingham CVD model and Wu’s simplified model. In addition, we developed a web calculator for physicians to conveniently generate CVD risk scores and identify those with a higher risk of CVD. We believe CVDMCM had great potential for clinical usage.
Publisher
Cold Spring Harbor Laboratory
Reference32 articles.
1. World Health Organization. Cardiovascular diseases (CVDs). Available from: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
2. The Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on Cardiovascular Health and Diseases in China 2019: an Updated Summary. Chinese Circulation Journal. 2020;35(09)
3. Cardiovascular epidemiology in the Asia-Pacific region
4. Epidemiology of cardiovascular disease in China: current features and implications
5. Cardiovascular disease risk profiles
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