A quiescent state following mild sensory arousal inCaenorhabditis elegansis potentiated by stress

Author:

McClanahan Patrick D.,Dubuque Jessica M.,Kontogiorgos-Heintz Daphne,Habermeyer Ben F.,Xu Joyce H.,Ma Anthony M.,Raizen David M.,Fang-Yen ChristopherORCID

Abstract

AbstractAn animal’s behavioral and physiological response to stressors includes changes to its responses to stimuli. How such changes occur is not well understood. Here we describe aCaenorhabditis elegansquiescent behavior, post-response quiescence (PRQ), which is modulated by theC. elegansresponse to cellular stressors. Following an aversive mechanical or blue light stimulus, worms respond first by briefly moving, and then become more quiescent for a period lasting tens of seconds. PRQ occurs at low frequency in unstressed animals, but is more frequent in animals that have experienced cellular stress due to ultraviolet light exposure as well as in animals following overexpression of epidermal growth factor (EGF). PRQ requires the function of the carboxypeptidase EGL-21 and the calcium-activated protein for secretion (CAPS) UNC-31, suggesting it has a neuropeptidergic mechanism. Although PRQ requires the sleep-promoting neurons RIS and ALA, it is not accompanied by decreased arousability, and does not appear to be homeostatically regulated, suggesting that it is not a sleep state. PRQ represents a simple, tractable model for studying how neuromodulatory states like stress alter behavioral responses to stimuli.

Publisher

Cold Spring Harbor Laboratory

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