Author:
Lechien Jerome R.,Cabaraux Pierre,Chiesa-Estomba Carlos M.,Khalife Mohamad,Hans Stéphane,Calvo-Henriquez Christian,Martiny Delphine,Journe Fabrice,Sowerby Leigh,Saussez Sven
Abstract
AbstractObjectiveTo investigate olfactory dysfunction (OD) in patients with mild COVID-19 through patient-reported outcome questionnaires and objective psychophysical testing.MethodsCOVID-19 patients with self-reported sudden-onset OD were recruited. Epidemiological and clinical data were collected. Nasal complaints were evaluated with the sino-nasal outcome-22 (SNOT-22). Subjective olfactory and gustatory status was evaluated with the National Health and Nutrition Examination Survey (NHNES). Objective OD was evaluated using psychophysical tests.ResultsEighty-six patients completed the study. The most common symptoms were fatigue (72.9%), headache (60.0%), nasal obstruction (58.6%) and postnasal drip (48.6%). Total loss of smell was self-reported by 61.4% of patients. Objective olfactory testings identified 41 anosmic (47.7%), 12 hyposmic (14.0%), and 33 normosmic (38.3%) patients. There was no correlation between the objective test results and subjective reports of nasal obstruction or postnasal drip.ConclusionA significant proportion of COVID-19 patients reporting OD do not have OD on objective testing.
Publisher
Cold Spring Harbor Laboratory
Cited by
3 articles.
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