Extrapolating acute bee sensitivity to insecticides using a phylogenetically informed interspecies scaling framework

Abstract

AbstractPlant protection products, including insecticides, are important for global food production. Historically, research of the adverse effects of insecticides on bees has focused on the honeybee (Apis mellifera), while non-Apis bee species remained understudied. Consequently, sensitivity assessment of insecticides for the majority of bees is lacking, which in turn hinders accurate risk characterization and consequently bee protection. Interspecies sensitivity extrapolation based on body weight offers a potential solution to this problem, but in the past such approaches have often ignored the phylogenetic background and consequently non independence of species used in such models. Using published data on the sensitivity of different bee species to commonly used insecticides, their body weight and phylogenetic background I build interspecies scaling models (ISMs) applying a phylogenetically informed framework. In addition, I compared, the relative sensitivity of the standard test species Apis mellifera to other bee species to evaluate their protectiveness when used as standards screening bee species in the risk assessment process. I found that overall 1) body weight is a predictor of bee sensitivity to insecticides for a range of insecticide classes and 2) A. mellifera is the most sensitive standard test species currently available and consequently a suitable surrogate species for ecotoxicological risk assessment.