SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area
Author:
Ng Dianna L., Goldgof Gregory M., Shy Brian R., Levine Andrew G., Balcerek Joanna, Bapat Sagar P., Prostko John, Rodgers Mary, Coller Kelly, Pearce Sandy, Franz Sergej, Du Li, Stone Mars, Pillai Satish K., Sotomayor-Gonzalez Alicia, Servellita Venice, Martin Claudia Sanchez San, Granados Andrea, Glasner Dustin R., Han Lucy M., Truong Kent, Akagi Naomi, Nguyen David N., Neumann Neil M., Qazi Daniel, Hsu Elaine, Gu Wei, Santos Yale A., Custer Brian, Green Valerie, Williamson Phillip, Hills Nancy K., Lu Chuanyi M., Whitman Jeffrey D., Stramer Susan, Wang Candace, Reyes Kevin, Hakim Jill M.C., Sujishi Kirk, Alazzeh Fariba, Pham Lori, Oon Ching-Ying, Miller Steve, Kurtz Theodore, Hackett John, Simmons Graham, Busch Michael P., Chiu Charles Y.ORCID
Abstract
ABSTRACTWe report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobulin-M, and in vitro neutralizing antibody titers in COVID-19 patients. Neutralizing antibodies rise in tandem with immunoglobulin levels following symptom onset, exhibiting median time to seroconversion within one day of each other, and there is >93% positive percent agreement between detection of immunoglobulin-G and neutralizing titers.
Publisher
Cold Spring Harbor Laboratory
Cited by
65 articles.
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