Abstract
AbstractBackgroundThe coronavirus (COVID-19) is now a global concern because of its higher transmission capacity and associated adverse consequences including death. The reproductive number of COVID-19 provides an estimate on possible extent of the transmission. This study aims to provide the average reproductive number of COVID-19 based on available global level evidence.MethodsWe searched three databases (PubMed, Web of Science, and Science Direct) to find studies reported the reproductive number of COVID-19. The searches were conducted using a pre-specified search strategy that includes keywords of COVID-19 and its reproductive number related terms, which were combined using the Boolean operators. We used meta-analysis to provide average reproduction number of COVID-19.ResultsTotal of 30 studies included in this review whereas 24 of them were included in the meta-analysis. The average estimated reproductive number was 2.70 (95% CI, 2.21-3.30). We found evidence of very high heterogeneity (99.5%) of the reproductive number reported in the included studies. The highest reproductive number was reported for Diamond Princes Cruise Ship, Japan (14.8). In the country-level, higher reproductive number was reported for France (R, 6.32, 95% CI, 5.72-6.98) following Germany (R, 6.07, 95% CI, 5.51-6.69) and Spain (R, 5.08, 95% CI, 4.50-5.73). We also found estimation models, methods, and the number of cases considered to estimate reproductive number were played a role in arising the heterogeneity of the estimated reproductive number.ConclusionThe estimated reproductive number indicates an exponential increase of COVID-19 infection in coming days. Comprehensive policies and programs are important to reduce new infections as well as the associated adverse consequences including death.
Publisher
Cold Spring Harbor Laboratory
Reference67 articles.
1. Coronavirus Update (Live) - Worldometer. In: Worldometer [Internet]. [cited 22 May 2020]. Available: https://www.worldometers.info/coronavirus/
2. WHO. Novel Coronavirus(2019-nCoV) Situation Report - 10. World Health Organization; 2020 Jan p. 7. Report No.: 10. Available: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200130-sitrep-10-ncov.pdf?sfvrsn=d0b2e480_2
3. SARS-CoV-2: The Path of Prevention and Control
4. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
5. First two months of the 2019 Coronavirus Disease (COVID-19) epidemic in China: real-time surveillance and evaluation with a second derivative model
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