Abstract
ABSTRACTNeurons in the intact brain receive a continuous and irregular synaptic bombardment from excitatory and inhibitory presynaptic neurons, which determines the firing activity of the stimulated neuron. In orderto investigate the influence of inhibitory stimulation on the firing time statistics, we consider Leaky Integrate-and-Fire neurons subject to inhibitory instantaneous postsynaptic potentials. In particular, we report exact results for the firing rate, the coefficient of variation and the spike train spectrum for various synaptic weight distributions. Our results are not limited to stimulations of infinitesimal amplitude, but they apply as well to finite amplitude post-synaptic potentials, thus being able to capture the effect of rare and large spikes. The developed methods are able to reproduce also the average firing properties of heterogeneous neuronal populations.
Publisher
Cold Spring Harbor Laboratory
Reference43 articles.
1. The high-conductance state of neocortical neurons in vivo
2. The Variable Discharge of Cortical Neurons: Implications for Connectivity, Computation, and Information Coding
3. Ricciardi L. M . Diffusion processes and related topics in biology, vol. 14 (Springer Science & Business Media, 2013).
4. Tuckwell H. C . Introduction to theoretical neurobiology: Volume 2, nonlinear and stochastic theories, vol. 8 (Cambridge University Press, 2005).
5. On the Distribution of Firing Rates in Networks of Cortical Neurons
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献