Abstract
AbstractThe complement system acts as central arm of innate immunity that is critical to host defense as well as the development of adaptive immunity. The origins of the complement system have so far been traced, which correlates to near to the beginnings of multi-cellular animal life. Owing to the difficulty in obtaining crystal structures of GPCRs in either inactive or active state, accurate structural modeling is still highly desirable for the majority of GPCRs. In an attempt to dissect the conformational changes associated with GPCR activation, computational modeling approaches is being pursued in this paper along with the evolutionary divergence to deal with the structural variability.
Publisher
Cold Spring Harbor Laboratory
Reference16 articles.
1. Patrick Joost and Axel Methner . Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands Patrick Joost and Axel Methner. Genome Biology (2002), 0063.1–0063.16.
2. Complement component 5a (C5a);Int J Biochem Cell Biol,2009
3. Hani Boshra , Jun Li , Rodney Peters , John Hansen , Anjan Matlapudi and J. Oriol Sunyer . Cloning, Expression, Cellular Distribution, and Role in Chemotaxis of a C5a Receptor in Rainbow Trout: The First Identification of a C5a Receptor in a Nonmammalian Species. The Journal of Immunology (2004), 4381–4390.
4. Gerard, N. P. , and C. Gerard . The chemotactic receptor for human C5a anaphylatoxin. Nature (1991), 349–614.
5. Bachvarov, D. R. , S. Houle , M. Bachvarova , J. Bouthillier , S.A. St. Pierre , Y. Fukuoka , J.A. Ember , and F. Marceau . Clonning and preliminary pharmacological characterization of the anaphylatoxin C5a receptor in the rabbit. Br. J. Pharmacol (1999), 128–321.