Abstract
The intricate molecular and structural sequences guiding the formation and consolidation of memories within neuronal circuits remain largely elusive. In this study, we investigate the roles of two pivotal presynaptic regulators, the small GTPase Rab3, enriched at synaptic vesicles, and the cell adhesion protein Neurexin-1, in the formation of distinct memory phases within theDrosophilamushroom body Kenyon cells. Our findings suggest that both proteins play crucial roles in memory-supporting processes within the presynaptic terminal, operating within distinct plasticity modules. These modules likely encompass remodeling and maturation of existing active zones (AZs), as well as the formation of new AZs.
Funder
NanoSYNDIV
ERC SynProtect
Fondation Fyssen
Bettencourt Schueller Foundation
China Scholarship Council
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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