Pulvinar influences parietal delay activity and information transmission between dorsal and ventral visual cortex in macaques

Abstract

AbstractThe fronto-parietal attention network represents attentional priorities and provides feedback about these priorities to sensory cortical areas. Sustained spiking activity in the posterior parietal cortex (PPC) carries such prioritized information, but how this activity is sustained in the absence of feedforward sensory information, and how it is transmitted to the ventral visual cortical pathway, is unclear. We hypothesized that the higher-order thalamic nucleus, the pulvinar, which is connected with both the PPC and ventral visual cortical pathway, influences information transmission within and between these cortical regions. To test this, we simultaneously recorded from the pulvinar, lateral intraparietal area (LIP) and visual cortical area V4 in macaques performing a selective attention task. Here we show that LIP influenced V4 during the delay period of the attention task, and that the pulvinar regulated LIP-V4 information exchange. Pulvino-cortical effects were consistent with the pulvinar supporting sustained activity in LIP. Taken together, these results suggest that pulvinar regulation of cortical functional connectivity generalizes to dorsal and ventral visual cortical pathways. Further, the pulvinar’s role in sustaining parietal delay activity during selective attention implicates the pulvinar in other cognitive processes supported by such delay activity, including decision-making, categorization and oculomotor functions.Significance StatementA network of areas on the brain’s surface, in frontal and parietal cortex, allocate attention to behaviorally relevant information around us. Such areas in parietal cortex show sustained activity during maintained attention and transmit behaviorally relevant information to visual cortical areas to enhance sensory processing of attended objects. How this activity is sustained and how it is transmitted to visual areas supporting object perception is unclear. We show that a subcortical area, the pulvinar in the thalamus, helps sustain activity in the cortex and regulates the information transmitted between the fronto-parietal attention network and visual cortex. This suggests that the thalamus, classically considered as a simple relay for sensory information, contributes to higher-level cognitive functions.