Author:
Wu Dong-Dong,Yang Cui-Ping,Wang Ming-Shan,Dong Kun-Zhe,Yan Da-Wei,Hao Zi-Qian,Fan Song-Qing,Chu Shu-Zhou,Shen Qiu-Shuo,Jiang Li-Ping,Li Yan,Zeng Lin,Liu He-Qun,Xie Hai-Bing,Ma Yun-Fei,Kong Xiao-Yan,Yang Shu-Li,Dong Xin-Xing,Koshkoiyeh Ali Esmailizadeh,Irwin David M,Xiao Xiao,Li Ming,Dong Yang,Wang Wen,Shi Peng,Li Hai-Peng,Ma Yue-Hui,Gou Xiao,Chen Yong-Bin,Zhang Ya-Ping
Abstract
AbstractAbundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we utilized 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provides insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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