Deep Brain Stimulation: Imaging on a group level
Author:
Treu Svenja, Strange BryanORCID, Oxenford Simon, Kühn AndreaORCID, Li NingfeiORCID, Horn AndreasORCID
Abstract
AbstractDeep Brain Stimulation (DBS) is an established treatment option for movement disorders and is investigated to treat a growing number of other brain disorders. It has been shown that DBS effects are highly dependent on exact electrode placement, which is especially important when probing novel indications or stereotactic targets. Thus, considering precise electrode placement is crucial when investigating efficacy of DBS targets. To measure clinical improvement as a function of electrode placement, neuroscientific methodology and specialized software tools are needed. Such tools should have the goal to make electrode placement comparable across patients and DBS centers, and include statistical analysis options to validate and define optimal targets. Moreover, to allow for comparability across different research sites, these need to be performed within an algorithmically and anatomically standardized and openly available group space. With the publication of Lead-DBS software in 2014, an open-source tool was introduced that allowed for precise electrode reconstructions based on pre- and postoperative neuroimaging data. Here, we introduce Lead Group, implemented within the Lead-DBS environment and specifically designed to meet aforementioned demands. In the present article, we showcase the various processing streams of Lead Group in a retrospective cohort of 51 patients suffering from Parkinson’s disease, who were implanted with DBS electrodes to the subthalamic nucleus (STN). Specifically, we demonstrate various ways to visualize placement of all electrodes in the group and map clinical improvement values to subcortical space. We do so by using active coordinates and volumes of tissue activated, showing converging evidence of an optimal DBS target in the dorsolateral STN. Second, we relate DBS outcome to the impact of each electrode on local structures by measuring overlap of stimulation volumes with the STN. Finally, we explore the software functions for connectomic mapping, which may be used to relate DBS outcomes to connectivity estimates with remote brain areas. We isolate a specific fiber bundle – which structurally resembles the hyperdirect pathway – that is associated with good clinical outcome in the cohort. The manuscript is accompanied by a walkthrough tutorial through which users are able to reproduce all main results presented in the present manuscript. All data and code needed to reproduce results are openly available.HighlightsWe present a novel toolbox to carry out DBS imaging analyses on a group-levelGroup electrodes are visualized in 2D and 3D and related to clinical regressorsA favorable target and connectivity profiles for the treatment of PD are validated
Publisher
Cold Spring Harbor Laboratory
Reference108 articles.
1. Akram, H. , Dayal, V. , Mahlknecht, P. , Georgiev, D. , Hyam, J. , Foltynie, T. , Limousin, P. , De Vita, E. , Jahanshahi, M. , Ashburner, J. , Behrens, T. , Hariz, M. , Zrinzo, L. , 2018. Connectivity derived thalamic segmentation in deep brain stimulation for tremor. NeuroImage Clin. https://doi.org/10.1016/j.nicl.2018.01.008 2. Akram, H. , Georgiev, D. , Mahlknecht, P. , Hyam, J. , Foltynie, T. , Limousin, P. , Jahanshahi, M. , Hariz, M. , Zrinzo, L. , Ashburner, J. , Behrens, T. , Sotiropoulos, S.N. , Jbabdi, S. , De Vita, E. , 2017. Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson’s disease. Neuroimage. https://doi.org/10.1016/j.neuroimage.2017.07.012 3. Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor;Brain,2019 4. Altinel, Y. , Alkhalfan, F. , Qiao, N. , Velimirovic, M. , 2019. Outcomes in Lesion Surgery versus Deep Brain Stimulation in Patients with Tremor: A Systematic Review and Meta-Analysis. World Neurosurg. https://doi.org/10.1016/j.wneu.2018.11.175 5. Amadeus Steiner, L. , Barreda Tomás, F.J. , Planert, H. , Alle, H. , Vida, I. , Geiger, J.R.P. , 2019. Connectivity and dynamics underlying synaptic control of the subthalamic nucleus. J. Neurosci. https://doi.org/10.1523/JNEUROSCI.1642-18.2019
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|