Pharmacological efficacy of a synergistic composition based on activators of cAMP accumulation as a wound healing agent

Abstract

AbstractIntroductionWound-healing dipyridamole- and papaverine-based aerosols (D1/D2) as activators of the accumulation of cyclic adenosine monophosphate are promising drugs that can accelerate wound healing in wound processes of various origins.Materials and methods128 rats were used in the study, including 38 in a pharmacological experiment on a model of stencil wounds and 90 in an experiment that studied the effect of spray on the number of CD34 cells in the blood of rats with chemically induced immunodeficiency. Immunodeficiency was caused by the fivefold administration of cyclophosphamide and prednisone. The expression level of CD34 was determined using flow cytofluorimeter.Results and discussionTopical application of D1/D2 aerosol samples on the skin of rats contributed to a statistically significant acceleration of regeneration processes. In terms of the appearance of granulations and epithelialization of wounds, D1/D2 aerosols were superior to dexpanthenol ointment. The maximum effect from the use of D1/D2 was observed on the 60th day, and restoration of the physiological level of pluripotent cells was observed as early as on the 10th day after the start of spray application. By accelerating wound healing, dipyridamole with papaverine probably stimulate the division of stem cells at the periphery without enhancing bone marrow function.