Global State Changes Induce Non-reciprocal Reduction of Mutual Information in the Thalamocortical Network

Abstract

AbstractUnderstanding the neural mechanisms of loss and recovery of consciousness remains an active area of scientific and clinical interest. Recent models and theories of consciousness implicate thalamus or neocortex as the dominant regions that control global state change, but experimentally testing these theories requires parsing the response properties of the complex thalamocortical network. In this work, we explore information processing using chronic recordings of multiunit activity between thalamus and cortex by targeting either the corticothalamic or thalamocortical pathway with direct electrical stimulation under subhypnotic and just-hypnotic states of isoflurane or dexmedetomidine induced unconsciousness. We found that mutual information between the stimulus and response in the corticothalamic circuit decreases with loss of consciousness, and that the change is not reciprocated in the thalamocortical direction. These changes in mutual information were moderately correlated with changes in evoked rate, and a strong effect of isoflurane on spontaneous and evoked rate accounts for a large portion of the change in mutual information. Further, we found cortical synchrony to increase under sub-and just-hypnotic doses of dexmedetomidine and isoflurane, suggesting cortical responses become more causally dependent on thalamocortical input at reduced levels of consciousness, or unconsciousness. We believe these changes suggest loss of consciousness is associated with a decrease in the number of available cortical network states, and may suggest cognitive unbinding from ascending sensory input.