Evolution of venom production in marine predatory snails

Author:

Zancolli Giulia,Modica Maria Vittoria,Puillandre Nicolas,Kantor Yuri,Barua Agneesh,Campli Giulia,Robinson-Rechavi Marc

Abstract

AbstractVenom is a widespread secretion in nature, extensively studied for its toxin components and application potential. Yet, the evolution of venom production remains poorly understood. To address this question, we conducted a comparative transcriptomics analysis of the oesophagus-associated glands in marine predatory gastropods, among which the cone snail venom gland represents a pinnacle of specialisation. We found that the functional divergence and specialisation of the venom gland was achieved through a redistribution of its ancestral digestive functions to other organs, specifically the oesophagus. This entailed concerted expression changes and accelerated transcriptome evolution across the entire digestive system. The increase in venom gland secretory capacity was achieved through the modulation of an ancient secretory machinery, particularly genes involved in endoplasmic reticulum stress and unfolded protein response. On the other hand, the emergence of novel genes, involving transposable elements, contributed to the gland regulatory network. Our analysis provides new insights into the genetic basis of functional divergence and highlights the remarkable plasticity of the gastropod digestive system.

Publisher

Cold Spring Harbor Laboratory

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3