Abstract
AbstractBackgroundThe repertoire of RNA-binding proteins (RBPs) in bacteria play crucial role for their survival, and interactions with the host machinery, but there is little information, record or characterisation in bacterial genomes. As a first step towards this, we have chosen the bacterial model system Escherichia coli, and organised all RBPs in this organism into a comprehensive database named EcRBPome.ResultsEcRBPome contains RBPs recorded from 166 complete E. coli proteomes available in the RefSeq database (as of May 2016). The database provides various features related to the E. coli RBPs, like their domain architectures, PDB structures, GO and EC annotations etc. It provides the assembly, bioproject and biosample details of each strain, as well as cross-strain comparison of occurrences of various RNA-binding domains (RBDs). The percentage of RBPs, the abundance of the various RBDs harboured by each strain have been graphically represented in this database and available alongside other files for user download.ConclusionTo the best of our knowledge, this is the first database of its kind and we hope that it will be of great use to the biological community. Database URL: http://caps.ncbs.res.in/ecrbpome
Publisher
Cold Spring Harbor Laboratory
Reference22 articles.
1. Messenger-RNA-binding proteins and the messages they carry;Nat Rev Mol Cell Biol [Internet],2002
2. Gamberi C , Johnstone O , Lasko P . Drosophila RNA binding proteins. Int. Rev. Cytol. 2006. p. 43–139.
3. A Compendium of Caenorhabditis elegans RNA Binding Proteins Predicts Extensive Regulation at Multiple Levels;G3|Genes|Genomes|Genetics [Internet],2013
4. A census of human RNA-binding proteins;Nature Publishing Group;Nat Rev Genet [Internet],2014
5. Genome-wide survey of putative RNA-binding proteins encoded in the human proteome;Mol BioSyst. Royal Society of Chemistry,2016