Chromosomal resolution reveals symbiotic virus colonization of parasitic wasp genomes
Author:
Gauthier Jérémy, Boulain Hélène, van Vugt Joke J.F.A.ORCID, Baudry Lyam, Persyn Emma, Aury Jean-MarcORCID, Noel Benjamin, Bretaudeau Anthony, Legeai Fabrice, Warris Sven, Chebbi Mohamed Amine, Dubreuil Géraldine, Duvic Bernard, Kremer Natacha, Gayral Philippe, Musset Karine, Josse Thibaut, Bigot Diane, Bressac Christophe, Moreau Sébastien, Periquet Georges, Harry Myriam, Montagné Nicolas, Boulogne Isabelle, Sabeti-Azad Mahnaz, Maïbèche Martine, Chertemps Thomas, Hilliou Frédérique, Siaussat David, Amselem Joëlle, Luyten Isabelle, Capdevielle-Dulac Claire, Labadie Karine, Merlin Bruna Laís, Barbe Valérie, de Boer Jetske G., Marbouty Martial, Cônsoli Fernando Luis, Dupas Stéphane, Hua Van Aurélie, Le Goff Gaëlle, Bézier Annie, Jacquin-Joly Emmanuelle, Whitfield James B., Vet Louise E.M., Smid Hans M., Kaiser-Arnault Laure, Koszul Romain, Huguet Elisabeth, Herniou Elisabeth A., Drezen Jean-Michel
Abstract
AbstractMost endogenous viruses, an important proportion of eukaryote genomes, are doomed to slowly decay. Little is known, however, on how they evolve when they confer a benefit to their host. Bracoviruses are essential for the parasitism success of parasitoid wasps, whose genomes they integrated ~103 million years ago. Here we show, from the assembly of a parasitoid wasp genome, for the first time at a chromosomal scale, that symbiotic bracovirus genes spread to and colonized all the chromosomes. Moreover, large viral clusters are stably maintained suggesting strong evolutionary constraints. Genomic comparison with another wasps revealed that this organization was already established ~53 mya. Transcriptomic analyses highlight temporal synchronization of viral gene expression, leading to particle production. Immune genes are not induced, however, indicating the virus is not perceived as foreign by the wasp. This recognition suggests that no conflicts remain between symbiotic partners when benefits to them converge.
Publisher
Cold Spring Harbor Laboratory
Cited by
3 articles.
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