Genetic risk scores of disease and mortality capture differences in longevity, economic behavior, and insurance outcomes

Author:

Linnér Richard KarlssonORCID,Koellinger Philipp D.ORCID

Abstract

AbstractWidespread genetic testing for diseases may cause adverse selection, escalating premiums, or discrimination in various insurance markets. Here, without systematically informing study participants of their genetic predisposition, we estimate to what extent genetic data are informative about differences in longevity, health expectations, and economic behavior. We compute measures of genetic liability (polygenic scores) for 27 common diseases and mortality risks in 9,272 participants of the Health and Retirement Study (HRS). Survival analysis suggests that the highest decile of cumulative genetic risk can distinguish a median lifespan up to 4.5 years shorter, a difference that is similar to or larger than that distinguished by conventional actuarial risk factors, including sex. Furthermore, greater genetic liability is associated with less long-term care insurance, among other economic behaviors. We conclude that the rapid developments in genetic epidemiology pose new challenges for regulating consumer genetics and insurance markets, requiring urgent attention from policymakers.

Publisher

Cold Spring Harbor Laboratory

Reference141 articles.

1. The Global State of the Genetic Counseling Profession;European Journal of Human Genetics : EJHG,2019

2. Abbott, Liam , Anttila Verneri , Krishna Aragam , Alex Baumann , Jon Bloom , Sam Bryant , Claire Churchhouse , et al. 2017. “RAPID GWAS OF THOUSANDS OF PHENOTYPES FOR 337,000 SAMPLES IN THE UK BIOBANK.” Nealelab.Is. 2017. http://www.nealelab.is/blog/2017/7/19/rapid-gwas-of-thousands-of-phenotypes-for-337000-samples-in-the-uk-biobank.

3. Genomic Risk Score Offers Predictive Performance Comparable to Clinical Risk Factors for Ischaemic Stroke;Nature Communications,2019

4. Life and Health Insurance Behaviour of Individuals Having Undergone a Predictive Genetic Testing Programme for Hereditary Non-Polyposis Colorectal Cancer;Community Genetics,2001

5. Direct-to-Consumer Testing 2.0: Emerging Models of Direct-to-Consumer Genetic Testing;Mayo Clinic Proceedings,2018

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