Author:
Naghynajadfard Maryam,Li Ying,Raisman Geoffrey
Abstract
Adult rats were trained to use their forepaw for retrieving a piece of noodle through a slit in the front of the cage. The dorsal corticospinal tract was lesioned by a focal stereotactic radio-frequency lesion at the level of the first/second cervical segment. Complete destruction of one side of the corticospinal tract completely prevented the use of the ipsilateral forepaw reaching for at least 6 months after operation. Rats which have shown no forepaw retrieval by 8 weeks were xenotransplanted with a suspension of cultured olfactory ensheathing cells derived from the mouse olfactory bulb, into the lesion site. Starting between 1 and 3 weeks, 10 rats with transplants bridging the lesion site resumed ipsilateral forepaw reaching. The histology of the lesioned rats with misplaced olfactory ensheathing cell showed no functional recovery during the 8 weeks of training.
Publisher
Cold Spring Harbor Laboratory
Reference12 articles.
1. Functional changes in astrocytes by human T-lymphotropic virus type-1 T-lymphocytes
2. The node of Ranvier in experimental allergic neuritis: an electron microscope study;J. Neurocytol,1975
3. Americam spinal injury association Net,http://www.asiaspinalinjury.org/elearning/elearning.php (accessed 26/06/14).
4. Olfactory Ensheathing Cells: Time Lapse Imaging of Cellular Interactions, Axonal Support, Rapid Morphologic Shifts, and Mitosis;The journal of comparative neurology,2003
5. Appel F , Holm J , Conscience JF , Schachner M , (1993), Several extracellular domains of the neural cell adhesion molecule L1 are involved in neurite outgrowth and cell body adhesion.