Abstract
AbstractBackgroundAtrial fibrillation (AF) is a prevalent clinical condition worldwide, with a high global incidence that significantly impacts disease burden and mortality rates. Single nucleotide polymorphisms inABCB1,ABCG2andCYP3A5are common, but the clinical outcomes are poorly understood. This study examines the association between the genetic variations ofABCB1, ABCG2andCYP3A5and the risk of AF in a Taiwanese population.MethodsThis case-control study recruited 216 AF patients from two hospitals in Taiwan between 2021 and 2023. Control groups were matched by age (± one year), gender, and AF-related variables from the Taiwan Biobank. Logistic regression analyzed the association between three genetic variants and AF risk.ResultsA significant association was noted betweenABCG2 rs2231142and AF risk. Those withABCG2 rs2231142 G/TandT/Tgenotypes had a 1.91-fold (95% CI = 1.04-3.53) increased risk of AF compared to those with the G/G genotype. This association was particularly pronounced in males in those carryingABCG2 rs2231143 T/Tgenotype having a 4.47-fold (95% CI = 1.02-19.67) increased risk after adjusting for covariates. There were no overall significant associations between AF risk and the polymorphisms ofABCB1 rs4148738andrs1128503,norCYP3A5 rs776746.ConclusionA robust risk association between theABCG2 rs2231142 T alleleand AF in Asian populations, particularly in male adults, suggests that genetic testing for this polymorphism could be integrated into risk assessment models for AF.
Publisher
Cold Spring Harbor Laboratory