Abstract
AbstractThe Information Theory of Aging (ITOA) provides a framework for understanding aging and rejuvenation through changes in epigenetic information. The work constructs a Waddington landscape — a 3D topology representing cells’ trajectories during changes in cell identity — from field decomposition of scRNA velocity data, and demonstrates that the Waddington landscape can serve as a mechanistic model of epigenetic information. It explains how aging-driven cellular functional decline and reprogramming-induced rejuvenation can be understood through transformations of the Waddington landscape. The paper offers insights into the representation of epigenetic information and how it may be manipulated to restore younger cellular states.
Publisher
Cold Spring Harbor Laboratory