Abstract
Age-related hearing loss is characterized by a progressive loss of threshold sensitivity, especially at high frequencies. There is increasing evidence that the loss of cilia in the inner and outer hair cells is the dominant cause of hearing loss. We present a framework for calculating the human auditory threshold based on a non-linear time-domain cochlear model that incorporates hair cell damage along the cochlear partition. We successfully predicted the audiogram measured prior to death by substituting the postmortem percentage of surviving hair cells, using data from Wu et al. (Wuet al., 2020). We also present an algorithm for estimating the percentage of hair cells from a measured audiogram. Comparison with the data from Wu et al. revealed that the algorithm accurately predicted the surviving inner hair cells along the entire cochlear partition and the outer hair cells at the basal part of the cochlea.
Publisher
Cold Spring Harbor Laboratory
Reference37 articles.
1. Time domina one-dimensional cochlear model with integrated tectorial membrane and outer hair cells;What Fire is in Mine Ears: Progress in Auditory Biomechanics,2011
2. Evoked mechanical responses of isolated cochlear outer hair cells;Science (New York, N.Y,1985
3. Integration of outer hair cell activity in a one-dimensional cochlear model;The Journal of the Acoustical Society of America,2004
4. Classifying human audiometric phenotypes of age-related hearing loss from animal models;Journal of the Association for Research in Otolaryngology,2013
5. Inner-hair-cell induced hearing loss: A biophysical modeling perspective;The Journal of the Acoustical Society of America,2023